Monitoring ATIS recording (frequency selected in the Com1/Com2) will let you know well in advance, of the active runway in use at your destination airport. If you find that a different runway is being used, you will have the time to make your changes accordingly! Most of the time things will happen the way you want them to, but occasionally you do have those times where someone has spoiled your desired plans. "It is, what it is!"
Same thing may happen on your desired takeoff runway! My favorite airport is Charleston, SC, and I usually anticipate taking off from RWY 33. I pull up ATIS, and I usually find that RWY 33 is in use for takeoff. If I don't pull up ATIS, I stand the chance of ground control clearing me to RWY 3, which is a long way from RWY 33. When that happens, I simply select, "Reset Flight", and then pull up ATIS and then the recording will state that RWY 33 is in use.
Another thing that I do like, is airports with parallel runways, ATC may clear you for RWY 5R (non-ILS runway), but, you have planned on landing on 5L (ILS runway). Sometimes FSX will offer you an option of requesting the alternate runway, and they usually will approve the requested change. This is a nice feature, but not always offered!
Anyway, we do as we are told, that way we stay out of trouble! We all get through the obstacles we are faced with.
Happy flying! Rick :cool: