Hi,
Thanks for the input Rob and MrZippy!
I checked for double assignments, but there were none.
I also tried several usb-ports, but it gave the same results.
This morning it came to my mind that it might have to do with (one of) the connections of the other devices: yoke, trimwheel, radiopanel, etc. that are all connected via a powered USB-hub.
So I disconnected the USB-hub and voila....X52 working like a charme. Throttle/AB working oke.
So now I have to find out wich of the devices caused the problem.
Very strange though that I never experienced this problem before; I have the USB-hub connected for a long time without any problem ?!
Well, at least I can fly the F-16 again!
Thank you for your advices/suggestions!