I’ve recently started using 124th and remember being able to select another runway during an IFR flight. I believe it was when ATC instructed me to expect a certain runway but can’t be sure. It was a button that could be selected as the third response at the bottom of the response box.
Try Ctrl + Shift + U. Totally from memory, but I believe that disables the Autorudder feature that links the aileron movement to the rudder for Mouse as Yoke or those without rudder pedals or joystick twist.
Kevin