There was Orbiter, and the Kerbal Space Program (?) that was once available but I don't think it is anymore.
You could do all kinds of Space oriented stuff; Apollo CSM/LM docking, STS Flights/Re-entry, etc.
Musk man and his Rocket company put out an ISS Docking Simulator to play with...
https://iss-sim.spacex.com/
h. Sapiens going to Mars? Not until the Shielding thing is figured out. Can't complete the Mission if Astros/Cosmos are too sick to work or their junk keeps falling off! Nope, we ain't ready to take that next step... yet.