In FS there is no Rwy 33L or Rwy 33R at CYYZ.
There is a Rwy 15L with a 33R secondary end, and a Rwy 15R with a 33L secondary end.
Both ends of a runway have to be set the same for closure/ openings to work correctly. If only one end is closed, FS sees that as an error in coding the airport and ignores such changes.
Setting 15L/33R for takeoff only is likely to increase go arounds on 15R/33L because of the 3,200 ft distance without a turnoff taxiway in the middle, but that is better than having 15L/33R basically closed for departures due to constant landings.
@ PawPaw's house - near KADS, Addison, Texas, USA