I'll see if I can answer all your questions. Firstly, whether you go Core 2 or Core i7 pretty much depends on how much you are willing to pay for extra performance. Core i7 is around 20% faster than Core 2 (if my memory serves me), but at least double the price. Personally I would stick with Core 2, I bought my current setup 6 months ago and am very happy with performance, it's really quick and didn't cost me all that much. But if you're willing to pay for it, Core i7 is the fastest out at the moment. The other thing to be aware of is that Core i7 motherboards are a lot more expensive than those for Core 2, since Core i7 hasn't gotten into the mainstream market yet, the boards are designed for enthusiasts.
Core 2 and Core Quad are from the same family of CPUs, so they use the LGA775 socket. Basically, if a motherboard's socket is LGA775, it will take a Core 2 or Quad CPU. Core i7 takes LGA1366 - it's a bigger CPU so it needs a bigger socket.
Chipset choice can be a hard one, not because it's hard to match-up with the CPU, but because there are so many to choose from. The most popular mainstream chipset at the moment is the Intel P45, it's good value for the features you get. I personally like Gigabyte's EP45-DS3 range (you can see I picked the R variant in my signature), but the ASUS P5Q range is also a popular choice.
There isn't much choice for Core i7, you either use the X58 chipset or the X58 chipset. But that will change in a while once the CPUs come down in price and become mainstream.

Originally Posted by
mgray1982
I've come across the Asus Striker Extreme MB, as it sounds like it's set up for max gaming.
Don't buy-into marketing hype, a $100 board will perform as well as a $200 or $300 one. Those expensive boards are really only needed if you're into serious overclocking, which I take it you aren't. Unless they have some killer feature they're a complete waste of money. And mainstream boards can overclock well too, my Q6600 is running at 3GHz, which is a 25% overclock.

Originally Posted by
mgray1982
I'm used to just picking a GPU card and plugging it in.
That's just like it is. I'm not quite sure what you mean when you say "integrated GPU". If you're talking about onboard graphics, included on the motherboard, then you don't need to worry about it, if you plug-in a discrete graphics card the computer will automatically figure out that the onboard chip isn't needed.
And remember - FSX isn't all that hard on graphics cards, don't buy the most expensive one thinking you'll get super-dooper performance. A more reasonably priced one will still give you good performance. Ones to look at are probably the NVIDIA 9800GT or ATi 4850, or if you want to run at a high resolution such as 1920x1200, the NVIDIA GTX260 ot ATi 4870. 4870 would be my pick of the bunch.
I think that's all, hope that helped.
Mike
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